Table 3 The significant subpathways identified by Subpathway-CorSP using metastatic prostate cancer data set (P < 0.05).
Subpathway ID | PathwayName | Subpathway-CorSP | Pathway-G | Pathway-M | IMPaLA | Subpathway-GM | Possible relation to the cancer | Reference (PMID) |
|---|---|---|---|---|---|---|---|---|
path:00260_1 | Glycine, serine and threonine metabolism | 3.88E-05 | 0.64728481 | 0.02756179 | 0.01784033 | 1 | De novo Purine synthesis | 19063642; 15229480 |
path:00561_1# | Glycerolipid metabolism | 0.00037304 | 0.42565344 | 0.36324046 | 0.15461455 | 0.12596684 | High energy demend and cell propagation | 18757836; 21802006 |
path:00563_1# | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | 0.00057710 | 0.51188267 | 1 | 1 | 1 | Suppress invasion of prostate and breast cancer cells | 16822939 |
path:00910_1 | Nitrogen metabolism | 0.00170052 | 0.06603059 | 0.29898906 | 0.01974242 | 0.02030707 | Enhance anti-cancer activity | 23746196; 26174441 |
path:00230_1 | Purine metabolism | 0.00253999 | 0.12987834 | 0.00018704 | 2.43E-05 | 0.20697902 | High DNA/RNA turnover in cancer | 19063642 |
path:00562_1 | Inositol phosphate metabolism | 0.00904761 | 0.54447931 | 0.41370312 | 0.22525279 | 0.02864760 | Membrane receptor signaling cascades and anti-cancer activity | 14608114; 20414202 |
path:00410_2 | beta-Alanine metabolism | 0.01083417 | 0.44423116 | 0.00070088 | 0.00031135 | 1 | Inhibit prostate cancer metastases | 22824219; 21071389 |
path:00480_1 | Glutathione metabolism | 0.01891404 | 0.66681313 | 0.01398493 | 0.00932534 | 0.01144082 | Impact resistance of cancer cells | 26056813; 25144624 |
path:00510_3# | N-Glycan biosynthesis | 0.02567615 | 0.22296249 | 1 | 1 | 1 | Efficient detection of prostate cancer | 18701493; 25154914 |
path:00983_4# | Drug metabolism-other enzymes | 0.02567615 | 0.97396069 | 1 | 1 | 1 | Metabolism of anti-cancer drug | 21215737; 21533940 |
path:00240_2 | Pyrimidine metabolism | 0.02716418 | 0.22648719 | 0.00770142 | 0.00174427 | 1 | Inhibition of metastatic prostate cancer | 25360799; 25178642 |
path:00603_1 | Glycosphingolipid biosynthesis- globo series | 0.02722552 | 0.06424124 | 1 | 1 | 0.00202817 | Tumor grade diagnosis and tumor prognosis | 26132161; 25715344 |
path:00601_1# | Glycosphingolipid biosynthesis- lacto and neolacto series | 0.03676192 | 1 | 1 | 1 | 1 | Cell adhesion and the growth of tumor cells | 20428086; 19658179 |
path:00740_2 | Riboflavin metabolism | 0.04837857 | 0.03385502 | 1 | 1 | 1 | Increase metastatic ability of prostate cells | 24791272; 17933458 |
