Figure 7 | Scientific Reports

Figure 7

From: siRNA capsulated brain-targeted nanoparticles specifically knock down OATP2B1 in mice: a mechanism for acute morphine tolerance suppression

Figure 7

Concentrations of morphine, M3G and M6G in brain OATP2B1 inhibition mediated acute morphine tolerance mice brain-tissues or plasma.

Concentrations of (A) morphine, (B) M3G and (C) M6G were determined by SPE-HPLC-MS/MS in acute morphine tolerance mice cerebrums, epencephalons and plasma with or without OATP2B1 knockdown in the brains. Pairwise comparisons were calculated using student t-test (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) (n = 6).

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