Figure 2

ApoE^−/− mice have a significantly lower parasite burden in the brain.

(A) Visualization and (B) quantification of brain luciferase activity in ApoE^−/− and WT mice using in vivo imaging. (C) Luciferase activity of infected WT and ApoE^−/− mice on day 9 post-infection assessed ex vivo. n = 5 for WT mice and n = 5 for ApoE^−/− mice; P = 0.0070. (D) Weight of brain, spleen and liver in infected WT (day 9 post-infection) and ApoE^−/− mice (day 24 post-infection). For the brain: n = 5 for WT mice and n = 5 for ApoE^−/− mice, P = 0.0022; for the spleen: n = 6 for WT mice and n = 3 for ApoE^−/− mice, P = 0.0238; and for the liver: n = 6 for WT mice and n = 3 for ApoE^−/− mice, P = 0.0238. (E) Representative pictures of spleens from WT (no infection and day 9 post-infection) and ApoE^−/− mice (day 24 post-infection). **P ≤ 0.01 and ***P ≤ 0.0001.