Figure 5
From: Mining gut microbiome oligopeptides by functional metaproteome display
Time course of serum reactivity.
Antibody response of mice sacrificed at life week 4, 6, 8, 12 and 18. (A) Histologic scoring of ileal inflammation (only 2 out of 10 wildtype samples were scored); serum reactivity with (B) JOZ158-E11 oligopeptide (C) JOZ158-G8 oligopeptide (D) JOZ156-H5 oligopeptide. The median cohort reactivity is indicated by a black line. Selected peptides were immobilized by streptavidin and bound serum antibodies from single sera (1:100 dilution) were detected with an anti-mouse (IgA, IgG, IgM) antibody. (Non-parametric Mann-Whitney test; * = p < 0.05; ** = p < 0.01; ***p < 0.001).
