Table 1 Genotype frequency of progeny from the mating of RCLG mice and EIIa-Cre mice.

From: Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality

Stage

No. of litters

Genotype (No. of offspring with the indicated genotype)

Total

G1

G2 (hemorrhage)

G2 (resorbed)

G2 (pale body surface)

G2 (no abnormal appearance)

E12.5

17

64

0

0

0

89

153

E13.5

15

53

0

0

0

75

128

E14.5

29

103

35

48

37

39

262

E15.5

23

70

13

75

18

27

203

E16.5

16

52

4

49

6

14

125

E17.5

9

25

1

35

1

3

65

Postnatal

20

85

0

0

0

0

85

  1. RCLG transgenic mice used here were heteroygous or homozygous, while EIIa-Cre mice used here were homozygous. The genotypes of offspring were determined by the combinational use of ex vivo bioluminescence and fluorescence imaging, as verified by PCR-based genotyping. The genetic background was FVB inbred mice. Genotype-1 (G1): Cre (control embryo), genotype-2 (G2): RCLG/Cre (mutant embryo).
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