Figure 7
From: CD200R/Foxp3-mediated signalling regulates microglial activation
Proposed model for Foxp3 modulation of microglial polarization.
Under normal physiological conditions, microglia exist in resting state, expressing CD200R, while nearby neurons express CD200. In the absence of neuronal expression of CD200, or when CD200R or Foxp3 expression in microglia is low, microglia undergo pro-inflammatory polarization, promoting neuroinflammation. When expression of CD200R or Foxp3 is elevated, anti-inflammatory polarization is enhanced, contributing to tissue repair and resolution of neuroinflammation.
