Figure 13
From: Thapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation
CHOP upregulation is critical for thapsigargin-stimulated TRAIL-induced apoptosis in nude mice carrying EC109 tumor xenografts.
(A) Photographs showing tumor xenograft morphologies in each group. (B) Change in body weight of the mice. (C) A tumor growth curve was drawn from the tumor volumes and treatment duration. (D) Representative Western blot results of CHOP, p-AMPK, DR5, Caspase 9, Bcl2, and Bax are shown. Membranes were re-probed for β-actin expression to show that similar amounts of protein were loaded in each lane. The results are expressed as the mean ± SD; n = 6. aP < 0.05 vs. the control group in EC109 cells.
