Figure 1 | Scientific Reports

Figure 1

From: The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior

Figure 1

Analysis of Mena11a expression in epithelial cancers.

Immunofluorescence of pan-Mena and Mena11a in primary mammary tumors from MMTV-PyMT transgenic mice at both the (A) adenoma and (B) early carcinoma stages. (A,B): DNA visualized with Hoechst staining. Scale bar, 20 μm. Images are representative of three independent experiments. (C) Association between metastatic stage and MenaCalc in COAD patient cohort; M0 = no evidence of distant metastasis, M1 = evidence of distant metastasis. For M0, n = 345 patients, for M1, n = 67 patients. Error bars: 95% CI. Wilcoxon rank-sum test ***p < 0.005. (D) GO term enrichment categories of the top 50 genes correlated with MenaCalc, Mena, and Mena11a in the COAD cohort.

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