Table 2 Dependence of salivary cortisol levels on internal and external variables.
From: Paradoxical diurnal cortisol changes in neonates suggesting preservation of foetal adrenal rhythms
Variable | n | Ln cortisol (nmol/L) | β | p | ||
|---|---|---|---|---|---|---|
Mean | 95% CI | |||||
A: Internal variable (diurnal difference) | ||||||
Morning | 62 | 1.76 (0.62) | 0.799 | (0.664, 0.962) | 0.018 | |
Evening | 62 | 1.99 (0.74) | Reference | |||
B: External variables | ||||||
Variables | n | Ln cortisol (nmol/L) | β | p | ||
Mean | 95% CI | Unadjusted | Adjusted | |||
Antenatal variables | ||||||
Pregnancy-induced hypertension | ||||||
Yes | 10 | 1.61 (0.63) | 0.731 | (0.547, 0.975) | 0.033 | 0.002 |
No | 52 | 1.92 (0.69) | Reference | |||
Antenatal glucocorticoid | ||||||
Yes | 29 | 1.77 (0.62) | 0.815 | (0.621, 1.071) | 0.142 | 0.794 |
No | 33 | 1.97 (0.74) | Reference | |||
Postnatal variables | ||||||
Delivery mode | ||||||
Vaginal | 26 | 2.06 (0.70) | 1.377 | (1.041, 1.823) | 0.025 | 0.087 |
Caesarean | 36 | 1.74 (0.65) | Reference | |||
Gestational age (week) | ||||||
<32 | 23 | 1.66 (0.56) | 0.543 | (0.389, 0.758) | <0.001 | 0.083 |
32 ≤ <36 | 31 | 1.93 (0.76) | 0.709 | (0.504, 0.997) | 0.048 | |
36≤ | 8 | 2.27 (0.57) | Reference | |||
Apgar score (5 min.) | ||||||
<7 | 8 | 1.65 (0.59) | 0.777 | (0.564, 1.069) | 0.121 | 0.467 |
7≤ | 54 | 1.91 (0.70) | Reference | |||
Need for invasive/non-invasive mechanical ventilation | ||||||
Yes | 31 | 1.71 (0.60) | 0.725 | (0.553, 0.950) | 0.020 | 0.391 |
No | 31 | 2.04 (0.75) | Reference | |||
Postnatal glucocorticoid | ||||||
Yes | 7 | 1.67 (0.62) | 0.793 | (0.508, 1.237) | 0.306 | 0.757 |
No | 55 | 1.90 (0.70) | Reference | |||
Variables on the day of study | ||||||
Age (day) | ||||||
≤5 | 10 | 2.17 (0.59) | Reference | NA | ||
5 < ≤14 | 21 | 1.94 (0.74) | 0.795 | (0.562, 1.124) | 0.194 | |
15 < ≤28 | 10 | 1.77 (0.71) | 0.673 | (0.461, 0.982) | 0.040 | |
28< | 21 | 1.71 (0.64) | 0.634 | (0.470, 0.855) | 0.003 | |
Blood sampling | ||||||
Yes | 19 | 2.08 (0.76) | 1.341 | (0.981, 1.834) | 0.066 | 0.457 |
No | 43 | 1.78 (0.64) | Reference | |||
Need for non-invasive mechanical ventilation | ||||||
Yes | 3 | 2.34 (0.24) | 1.635 | (1.271, 2.104) | <0.001 | <0.001 |
No | 59 | 1.85 (0.70) | Reference | |||
