Table 2 Independent genetic associations of RGS1 and RASGRP1 variants in IgA nephropathy.

From: Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy

Chr

SNP

IgAN discovery

IgAN replication

IgAN in total

MAF case/control (%)

P

OR

95% CI of OR

MAF case/control (%)

P

OR

95% CI of OR

P

OR

95% CI of OR

1

rs12022418

36.48/31.67

6.27 × 10−4

1.24

1.10–1.40

37.00/32.13

2.88 × 10−3

1.15

1.05–1.26

3.00 × 10−6

1.23

1.13–1.34

15

rs7170151

49.39/44.47

8.34 × 10−4

1.22

1.09–1.37

49.80/45.27

9.05 × 10−3

1.20

1.05–1.38

1.90 × 10−5

1.20

1.10–1.30

  1. Discovery cohort: 1,248 patients with sporadic IgAN, and 1,187 controls.
  2. Replication cohort: 500 patients with sporadic IgAN, and 2,372 controls.
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