Table 3 Dose (D) of BPDEs in the hSA mixture and rate constants for reactions with histidine (kHis-Pro) and lysine (kLys).

From: Interaction of benzo[a]pyrene diol epoxide isomers with human serum albumin: Site specific characterisation of adducts and associated kinetics

BPDE isomers

D (mM·h)

kHis-Pro (L·g−1·h−1)

kLys (L·g-1·h-1)

(±)-anti-

0.83

1.7 × 10-6

1.7 × 10-6

(+)-anti-

0.078

3.6 × 10-6

2.8 × 10−5

(−)-anti-a

1.6

n.d.

n.d.

(±)-syn-

0.099

1.3 × 10−5

1.9 × 10−5

  1. a(−)-anti-BPDE values were estimated based on the racemic (±)-anti- and enantiomer (+)-anti-BPDE; n.d., not determined.
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