Figure 1 | Scientific Reports

Figure 1

From: X-Ray based Lung Function measurement–a sensitive technique to quantify lung function in allergic airway inflammation mouse models

Figure 1

Breathing modulates the x-ray transmission at the chest region over time.

(a) shows an exemplified radiograph: the average x-ray transmission function over time (XTF) is measured in a region of interest of the lung (ROI) and normalized by the background intensity (ROIBgk); and (b) shows exemplary two breathing cycles of a healthy control animal CN (blue curve); a mouse from the severe acute airway inflammation model (SAA) two days after the last challenge (red curve) and a mouse from the same model that had been treated with dexamethasone before each challenging step (SAA-DEX, green curve). The SAA mouse demonstrates a strong reduction in the area under the curve due to the lower air content within the lung at peak inspiration and an asymmetric shape of the breathing event with a shorter time to peak. The treated mouse (SAA-DEX) shows XTF properties comparable to those obtained in the healthy control mouse CN.

Back to article page