Table 1 Characteristics of the study population.

From: Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Variable

Type 2 diabetes Patients

Healthy Subjects

P-value

N = 48

N = 12

Age (years)

57.5 ± 5.4

57.7 ± 6.7

0.940

Time since diagnosis of diabetes (years)

4.0 ± 2.5

 

Body mass index (kg/m2)

29.2 ± 3.5

26.8 ± 2.1

0.005*

Waist circumference (cm)

106.4 ± 9.8

98.8 ± 8.9

0.021*

Subcutaneous fat volume (mL)

706.6 ± 248.4

558.6 ± 209.7

0.063

Visceral fat volume (mL)

444.65 ± 206.6

324.5 ± 125.2

0.060

Systolic blood pressure (mm Hg)

128.1 ± 12.2

112.6 ± 9.3

<0.001*

Diastolic blood pressure (mmHg)

75.9 ± 6.1

76.2 ± 9.0

0.931

Heart rate (bpm)

65.7 ± 8.5

61.1 ± 9.8

0.082

Concomitant medication N (%)

 Statin

25 (52.1)

 

 Any antihypertensive medication

21 (43.8)

 

 β-Blocker

6 (12.5)

 

 Diuretic

11 (22.9)

 

 ACE inhibitor

10 (20.8)

 

 ARB

5 (10.4)

 

 Calcium antagonist

3 (6.3)

 

HbA1c (%)

7.2 ± 1.0

 

Plasma fasting glucose (mmol/L)

9.0 ± 2.1

5.3 ± 0.4

<0.001*

Plasma fasting insulin (pmol/L)

66.8 ± 35.4

42.6 ± 22.2

0.009*

Total cholesterol (mmol/L)

4.6 ± 0.9

5.1 ± 0.5

0.114

LDL cholesterol (mmol/L)

2.7 ± 0.8

3.3 ± 0.5

0.022*

HDL cholesterol (mmol/L)

1.1 ± 0.3

1.3 ± 0.2

0.057

Plasma triglycerides (mmol/L)

1.8 ± 1.1

1.1 ± 0.5

0.017*

Plasma NEFA (mmol/L)

0.5 ± 0.2

0.5 ± 0.2

0.990

us-CRP (mg/L)

5.3 ± 4.2

6.3 ± 3.7

0.261

NT-proBNP (ng/L)

38.4 ± 29.8

36.6 ± 24.2

0.952

  1. Data are presented as mean ± SD for continuous variables and as frequencies (percentages) for categorical variables. *Statistically significant. ACE: Angiotensin-converting enzyme; ARB: angiotensin receptor blocker; HbA1c: Glycated haemoglobin. For other abbreviations see the text.