Scientific Reports

Table 2 Associations between parameters of cardiac dimensions and function and circulating lncRNAs in patients with well-controlled type 2 diabetes.

From: Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

	mean ± SD	LIPCAR		uc004cos.4		uc004cov.4		uc004coz.1		uc011mfi.2		uc022bqu.1		uc022bqw.1		MIAT		SENCR
	mean ± SD	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value	β	P-value
LV dimensions
LV mass (g)	108.1 ± 18.2	−0.088	0.556	−0.111	0.464	−0.162	0.283	−0.205	0.167	−0.197	0.179	−0.163	0.275	−0.176	0.236	0.072	0.626	0.170	0.248
LV end-systolic volume (mL)	61.1 ± 14.3	−0.038	0.799	−0.103	0.496	−0.067	0.660	−0.114	0.444	−0.086	0.563	−0.025	0.867	−0.040	0.788	−0.220	0.132	−0.238	0.104
LV end-diastolic volume (mL)	155.7 ± 24.9	−0.149	0.316	−0.191	0.204	−0.179	0.234	-0.200	0.177	−0.156	0.288	−0.135	0.364	−0.170	0.253	−0.289	0.046*	−0.236	0.107
LVMV-ratio (g/mL)	0.7 ± 0.1	0.058	0.696	0.067	0.656	0.006	0.969	−0.011	0.940	−0.031	0.836	−0.035	0.813	−0.004	0.977	0.376	0.008*	0.375	0.009*
LV systolic function
LV Stroke volume (mL)	94.6 ± 17.1	−0.186	0.210	−0.189	0.209	−0.202	0.179	−0.196	0.188	−0.157	0.288	−0.176	0.235	−0.214	0.149	−0.238	0.104	−0.146	0.324
LV Ejection Fraction (%)	60.8 ± 5.8	−0.059	0.694	−0.001	0.994	−0.046	0.762	0.012	0.935	0.010	0.947	−0.068	0.650	−0.077	0.606	0.036	0.810	0.101	0.494
Cardiac index (L/min * m⁻²)	3022 ± 540	−0.058	0.697	−0.131	0.386	−0.117	0.440	−0.081	0.587	0.009	0.954	−0.057	0.705	−0.039	0.793	−0.165	0.262	−0.152	0.302
LV diastolic function
E peak filling rate (mL/s)	419.5 ± 82.6	−0.296	0.044*	−0.259	0.082	−0.262	0.078	−0.272	0.064	−0.185	0.209	−0.245	0.096	−0.256	0.082	−0.181	0.218	−0.234	0.110
E-dec_peak (mL/s² *10⁻³)	−3.5 ± 1.0	0.335	0.022*	0.316	0.032*	0.334	0.023*	0.315	0.031*	0.266	0.067	0.279	0.058	0.300	0.040*	0.152	0.301	0.432	0.002*
E−dec_mean (mL/s² *10⁻³)	−2.3 ± 0.6	0.459	0.001*	0.432	0.003*	0.435	0.003*	0.422	0.003*	0.338	0.019*	0.408	0.004*	0.422	0.003*	0.154	0.296	0.320	0.027*
E/A peak flow	1.0 ± 0.2	−0.413	0.004*	−0.366	0.012*	−0.381	0.009*	−0.338	0.020*	-0.333	0.021*	−0.355	0.014*	−0.380	0.008*	−0.118	0.423	−0.264	0.070
E/Ea	9.3 ± 3.4	0.022	0.891	0.092	0.563	0.083	0.608	0.070	0.660	−0.032	0.837	0.140	0.378	0.147	0.354	0.142	0.365	−0.108	0.489
Myocardial steatosis
Neutral lipid content (%)	0.9 ± 0.4	0.010	0.945	0.062	0.683	0.051	0.737	0.146	0.327	0.110	0.456	−0.014	0.927	−0.037	0.803	0.023	0.875	0.132	0.371

*Statistically significant. A: Atrial contraction; E: Early diastolic filling phase; E/Ea: Estimation of left ventricular filling pressures; LV: Left ventricular; LVMV: Left ventricular mass/left ventricular end-diastolic volume.

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