Table 5 Association between LV diastolic dysfunction and circulating lncRNAs in patients with well-controlled type 2 diabetes.

From: Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

 

OR (95% IC)

P-value

Univariate analysis

 LIPCAR

1.047 (1.008, 1.087)

0.017*

 uc004cos.4

1.033 (1.006, 1.062)

0.018*

 uc004cov.4

1.172 (1.027, 1.337)

0.018*

 uc004coz.1

1.040 (1.004, 1.077)

0.027*

 uc011mfi.2

1.107 (1.019, 1.203)

0.017*

 uc022bqw.1

1.043 (1.006, 1.082)

0.022*

 uc022bqu.1

1.049 (1.008, 1.093)

0.020*

 H19

1.959 (0.469, 9.178)

0.356

 HOTAIR

1.067 (0.904, 1.259)

0.446

 MIAT

0.890 (0.170, 4.666)

0.890

 SENCR

1.673 (0.119, 3.545)

0.703

Multivariate analysis

Model 1

  LIPCAR

1.053 (1.007, 1.101)

0.023*

  Age

1.090 (0.957, 1.240)

0.195

  BMI

1.171 (0.938, 1.462)

0.163

Model 2

Association between LV diastolic dysfunction and circulating LIPCAR for model 1 and each of following variables:

 Plasma fasting glucose

1.058 (1.008, 1.111)

0.022*

 Plasma fasting insulin

1.046 (1.002, 1.091)

0.040*

 Time since diagnosis of diabetes

1.048 (1.003, 1.094)

0.034*

 Myocardial Steatosis

1.054 (1.007, 1.103)

0.024*

 HDL cholesterol

1.049 (1.005, 1.095)

0.030*

 SBP

1.053 (1.007, 1.101)

0.022*

 DBP

1.052 (1.006, 1.100)

0.025*

 Heart rate

1.056 (1.008, 1.106)

0.021*

 us-CRP

1.045 (1.001, 1.091)

0.044*

 NT-proBNP

1.064 (1.013, 1.118)

0.013*

  1. OR: Odds Ratio, CI: Confidence Interval. *Statistically significant.