Figure 4 | Scientific Reports

Figure 4

From: Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target

Figure 4

Acidic pH induces a more catabolic phenotype in NP cells.

Gene expression of (a) matrix proteins, including VCAN, COL1 and COL2A1, (b) matrix degrading enzymes, including MMP-3, ADAMTS-4 and -5, and TIMPs-1, -2 and -3, by NP cells (n = 3) cultured at pH 7.1, 6.8 and 6.5 for 7 days and normalised to MRPL19 and gene expression at pH 7.4. *Indicate p ≤ 0.05.

Back to article page