Table 3 Prognostic analysis of clinical characteristics for DMFS.

From: Genetic variations in the PI3K-PTEN-AKT-mTOR pathway are associated with distant metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy

Covariate

Univariate analysis

Multivariate analysis

HR (95%CI)

p-value

HR (95%CI)

p-value

age

1.007 (0.987, 1.028)

0.472

1.008 (0.988, 1.029)

0.410

gender

 

0.527

 

0.578

 male

reference

 

reference

 

 Female

0.853 (0.521,1.396)

 

0.869 (0.530,1.425)

 

T classification

 

0.915

 

0.950

 T1

reference

 

reference

 

 T2

1.082(0.515,2.267)

 

1.006 (0.479,2.116)

 

 T3

1.062 (0.542,2.080)

 

0.987 (0.500,1.945)

 

 T4

1.229 (0.673,2.246)

 

1.149 (0.625,2.113)

 

N classification

 

0.001

 

<0.001

 N0

reference

 

reference

 

 N1

2.322 (0.544,9.902)

 

2.509 (0.580, 10.853)

 

 N2

5.899 (1.412,24.650)

 

6.507 (1.526, 27.740)

 

 N3

9.350 (2185,40.019)

 

10.807 (2.451,47.653)

 

Chemotherapy-

 

0.634

 

0.418

 ≤3 cycles

reference

 

reference

 

 >3 cycles

1.123 (0.697,1.810)

 

0.808 (0.483,1.353)

 
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