Table 4 Prognostic analysis of individual SNPs for DMFS.

Covariate	No. of patients	Univariate analysis		Multivariate analysis
Covariate	No. of patients	3y DMFS(%)	p-value	HR (95%CI)	p-value
PI3KCA:rs6443264			0.069		0.151
TT	68	92.0		Reference
TG or GG	428	84.2		1.958 (0.782,4.905)
PI3KCA:rs2699887			0.384		0.456
GG	451	84.7		Reference
GA or AA	40	89.7		0.680 (0.247,1.875)
AKT1:rs1130214			0.029		0.075
GG	369	86.9		Reference
GT or TT	111	78.0		1.566 (0.956,2.567)
AKT1:rs3803304			0.592		0.649
CC	412	84.7		Reference
CG or GG	84	86.8		0.861(0.452,1.640)
AKT1:rs2494738			0.106		0.027
GG	85	80.5		Reference
GA or AA	377	86.9		0.530 (0.302,0.929)
AKT1:rs2498804			0.208		0.221
TT	203	87.6		Reference
TG or GG	288	83.2		1.354 (0.833,2.200)
AKT1:rs249732			0.162		0.124
CC	257	87.6		Reference
CT or TT	220	83.1		1.450 (0.903,2.328)
AKT1:rs3803300			0.025		0.045
GG	52	74.5		Reference	.
GA or AA	424	86.7		0.536 (0.292,0.986)
AKT2:rs2304186			0.757		0.625
GG	115	88.0		Reference
GT or TT	373	84.6		1.151(0.656,2.020)
AKT2:rs892119			0.219		0.075
GG	356	84.1		Reference
GA/AA	110	88.0		0.579 (0.317–1.057)
mTOR:rs11121704			0.165		0.085
TT	422	86.3		Reference
CT or CC	74	79.5		1.655 (0.933,2.935)
mTOR:rs2295080			0.949	0	0.739
TT	307	85.6		Reference
GT or GG	189	84.7		1.065 (0.665,1.707)
PTEN:rs2299939			0.470		0.560
CC	331	84.5		Reference
CA or AA	163	86.7		0.862 (0.522,1.422)
PTEN:rs11202607			0.460		0.569
CC	385	84.4		Reference
CT or TT	111	88.1		0.844 (0.471,1.512)
PTEN:rs701848			0.660		0.488
TT	162	84.7		Reference
TC or CC	329	85.3		0.844 (0.523,1.363)
PTEN:rs12569998			0.539		0.458
TT	198	83.4		Reference
TG/GG	297	86.5		0.840 (0.529–1.333)

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