Figure 6 | Scientific Reports

Figure 6

From: Infusion with Human Bone Marrow-derived Mesenchymal Stem Cells Improves β-cell Function in Patients and Non-obese Mice with Severe Diabetes

Figure 6

Infused MSCs migrate and accumulate in the pancreatic tissues in diabetic NOD mice.

Following infusion with MSCs, some mice from each group were sacrificed and their lung, liver, intestine, kidney and pancreatic tissues were dissected. The levels of human Alu element DNA were determined by quantitative RT-PCR and analyzed, according to the standard curve. Data are expressed as the mean ± SEM of individual groups of mice (n = 6 per group per time points). Statistical significance was analyzed by ANOVA and post hoc Fisher’s least significant difference test. *P < 0.05 vs. the low-dose group. †P < 0.05 vs. the high-dose group. ‡P < 0.05 vs. the mice at 14 days post treatment. §P < 0.05 vs. the mice at 42 days post treatment.

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