Figure 2 | Scientific Reports

Figure 2

From: Validation of plasma microRNAs as biomarkers for myotonic dystrophy type 1

Figure 2

miR-133b validation as DM1 biomarker.

(a) Box plot of miR-133b levels in the plasma of DM1 and controls (CTR; ****p < 0.0001). (b) ROC curve illustrating sensitivity and specificity of plasma miR-133b in discriminating healthy from diseased patients. (c) Spearman’s inverse correlation between miRNA-133b fold change compared to CTR and muscle strength measured by MRC megascore. (d) Spearman’s direct correlation between miRNA-133b fold change compared to CTR and CK plasma levels. For all panels, DM1 n = 103, CTR n = 111.

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