Figure 3
From: Validation of plasma microRNAs as biomarkers for myotonic dystrophy type 1
DM1-miRNA score validation as DM1 biomarker.
The DM1-miRNA score was calculated averaging the fold changes of miR-1, -133a, -133b, -140-3p, -206, -27b, -454 and -574 in the plasma of DM1 and controls (DM1 n = 103, CTR n = 111). (a) Box plot of DM1-miRNA score levels in the plasma of DM1 and controls (CTR; ****p < 0.0001). (b) ROC curve illustrating sensitivity and specificity of the DM1-miRNA score in discriminating healthy from diseased patients. (c) Spearman’s inverse correlation between the DM1-miRNA score and muscle strength measured by MRC megascore. (d) Spearman’s direct correlation between the DM1-miRNA score and CK plasma levels.
