Figure 5
From: Validation of plasma microRNAs as biomarkers for myotonic dystrophy type 1
miR-133 a/b score validation as DM1 biomarker.
The miR-133a/b score was calculated averaging the fold changes of miRNA-133a and -133b in the plasma of DM1 and controls (DM1 n = 103, CTR n = 111). (a) Box plot of miR-133a/b score levels in the plasma of DM1 and controls (CTR; ****p < 0.0001). (b) ROC curve illustrating sensitivity and specificity of the miR-133a/b score in discriminating healthy from diseased patients. (c) Spearman’s inverse correlation between the miR-133a/b score and muscle strength measured by MRC megascore. (d) Spearman’s direct correlation between the miR-133a/b score and CK plasma levels.
