Figure 1
Enhanced Expression of TRPM2 in Human Carcinoma of Tongue Specimens.
(A) Highly positive immunohistochemical staining of TRPM2 in human carcinoma of tongue specimens (C1, ×40; C2, ×200), negative staining of TRPM2 in non-malignant tongue tissues (A1, ×40; A2, ×200), and weakly TRPM2 positive staining in papilloma of tongue specimens (B1, ×40; B2, ×200). Bar = 50 μm. (B) TRPM2 mRNA levels are increased in the tongue specimens of carcinoma. TRPM2 mRNA levels were quantified for real-time PCR and displayed as average ± s.e.m. in the histogram (n = 3 per group). (C) Expression of TRPM2 protein levels in the tongue specimens of carcinoma is enhanced compared with that in control and papilloma groups. The tongue specimens from carcinoma, papilloma and control patients (n = 3 per group) are dissected and subjected to western blotting, and optical density is displayed as average ± s.e.m. in the histogram. **p < 0.01, ***p < 0.001 compared with the control group. #p < 0.05, ##p < 0.01 compared with the papilloma group.
