Table 1 List of significantly altered metabolites between injured and non-injured CSF and serum samples.

From: Parallel Metabolomic Profiling of Cerebrospinal Fluid and Serum for Identifying Biomarkers of Injury Severity after Acute Human Spinal Cord Injury

CSF metabolites

A VS. N

B VS. N

C VS. N

p-value

FC

q-value

p-value

FC

q-value

p-value

FC

q-value

Uridine

2.74E-08

0.29

6.82E-07

1.39E-09

0.25

3.12E-08

2.83E-04

0.37

0.00523

Imidazoleacetic acid

2.09E-04

0.45

0.00149

0.00322

0.56

0.0206

0.00527

0.52

0.0406

Methionine Sulfoxide

1.25E-05

0.46

1.56E-04

8.72E-05

0.50

0.00131

1.22E-04

0.43

0.00300

Arginine

2.97E-06

0.50

4.93E-05

0.00164

0.62

0.0123

0.00177

0.59

0.0206

Cystathionine

0.0180

3.78

0.0386

0.00373

3.07

0.0209

0.0139

2.63

0.0770

Homocarnosine

0.00582

3.79

0.0159

0.00493

3.22

0.0212

0.0186

3.43

0.0899

Alpha-aminobutyric acid

0.0157

1.68

0.0355

0.00153

1.90

0.0123

0.0312

1.44

0.121

N-Acetylputrescine

3.69E-04

1.92

0.00153

0.00568

1.58

0.0212

0.0982

1.28

0.220

N-methyl-D-aspartic acid

0.00328

2.34

0.00961

0.0301

1.54

0.0644

0.546

0.91

0.615

Lysine

3.08E-04

0.53

0.00153

0.00657

0.69

0.0227

3.71E-05

0.58

0.00274

2-Aminobenzoic acid

0.00104

1.60

0.00345

0.0755

1.51

0.130

0.00195

1.53

0.0206

Proline

6.35E-04

3.54

0.00243

0.140

6.66

0.159

0.0146

3.09

0.0770

2-Phenylglycine

0.297

0.81

0.242

0.0164

0.65

0.0433

0.0200

0.48

0.0899

Ethanolamine

3.86E-05

0.59

3.20E-04

0.0271

0.70

0.0608

0.0124

0.69

0.0763

Citrulline

0.0286

1.58

0.0526

0.356

1.18

0.250

0.336

0.83

0.469

Cadaverine

0.0143

1.64

0.0339

0.154

2.30

0.162

0.773

0.96

0.715

Glycylproline

0.0277

1.73

0.0526

0.145

1.60

0.159

0.243

1.23

0.408

Lactic acid

1.83E-05

2.12

1.82E-04

0.0221

1.49

0.0522

0.0307

1.29

0.121

Glycerol

2.87E-04

2.48

0.00153

0.0550

1.52

0.112

0.238

1.24

0.408

Oxidized glutathione

0.0194

3.58

0.0386

0.102

1.99

0.150

0.231

2.61

0.408

Gamma-Aminobutyric acid

0.188

1.67

0.184

0.0155

2.11

0.0433

0.126

1.58

0.266

Threonine

6.07E-03

0.68

0.0159

0.0957

0.81

0.148

0.00610

0.65

0.0410

Isoleucine

6.85E-02

0.60

0.0948

0.0923

0.63

0.148

0.0484

0.62

0.162

5-Hydroxyindoleacetic acid

1.29E-01

1.36

0.153

0.0693

1.52

0.124

0.0458

1.96

0.162

Serum metabolites

A VS. N

B VS. N

C VS. N

p -value

FC

q -value

p -value

FC

q -value

p -value

FC

q -value

Uridine

1.90E-05

0.43

5.01E-04

1.27E-06

0.41

3.56E-05

1.34E-05

0.35

4.86E-04

4-Hydroxyproline

0.00384

0.62

0.0221

0.0108

0.65

0.0757

0.0210

0.63

0.0951

N1, N12-Diacetylspermine

0.00163

2.06

0.0145

0.00846

1.96

0.0757

0.0364

1.63

0.134

Glycylproline

1.88E-04

3.20

0.00372

0.0421

2.51

0.169

1.59E-04

3.09

0.00230

Sarcosine

0.00670

0.54

0.0332

0.0644

0.68

0.208

0.0135

0.58

0.0753

Phenylalanine

1.21E-05

1.60

4.79E-04

6.38E-06

1.43

1.34E-04

5.92E-05

1.56

0.00107

2-Aminooctanoic acid

0.0489

0.67

0.125

0.00138

0.55

0.0194

0.0256

0.56

0.109

5-Hydroxylysine

0.199

1.14

0.323

0.0237

1.51

0.127

0.00361

1.72

0.0262

Hydroxyphenyllactic acid

0.00341

1.56

0.0221

0.0159

1.48

0.0956

0.137

1.31

0.333

Guaiacol

0.0120

1.59

0.0545

0.170

1.22

0.353

0.806

1.06

0.664

N-Acetylputrescine

0.0271

2.46

0.0825

0.0887

2.18

0.228

0.0712

1.80

0.206

Vanillylmandelic acid

0.00506

1.50

0.125

0.0106

1.50

0.0757

0.624

1.11

0.595

Alpha-aminobutyric acid

0.0192

1.44

0.0675

7.93E-04

1.80

0.0133

0.00362

1.49

0.0262

  1. Fold change (FC) and p-value that met the selection criteria (fold change >1.5, p < 0.05) are shown in bold.
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