Figure 7
From: Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway
Conduction velocities of compound action potentials in the spinal cords of p35 and JNK3 knockout mice.
Determination of conduction velocities of CAPs in p35 (A) and JNK3 (B) KO and WT mice. Representative CAPs from spinal cords of p35 (p35 KO; n = 6) and JNK3 (JNK3 KO; n = 7) KO and their wild-type mice (n = 6 for P35 WT; n = 10 for JNK3 WT). Representative CAPs recorded at 24 °C and 37 °C from spinal cords of APP KO and WT mice (upper panel). The conduction velocity measured in WT mouse spinal cord (open bars) was consistently higher than that seen in APP KO mice (closed bars) at both temperatures measured (lower panel). N numbers are indicated inside the bars. Student’s t-test, *p < 0.05; **p < 0.01. Error bars represent mean ± S.E.
