Table 2 Association between MDM2rs2279744 and MDM2rs937283 genotypes and disease recurrence in 1008 patients with SCCOP.

From: Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx

Genotypes

No. of recurrences/no. of patients

5-year recurrence rate, %

Log-rank P value

aHR * (95% CI)

MDM2rs2279744

  

< 0.0001

 

 GT/GG †

52/451

10

 

1.0

 TT

129/557

24

 

2.0 (1.5–2.8)

MDM2rs937283

  

<0.0001

 

 AG/GG †

77/797

10

 

1.0

 AA

104/211

52

 

6.2 (4.6–8.3)

  1. aHR, adjusted hazard ratio; CI, confidence interval.
  2. *Adjusted for age, sex, ethnicity, smoking status, alcohol use status, disease stage, comorbidity, and treatment.
  3. †Reference group.
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