Figure 2: Hepatic inhibition miR-291b-3p expression ameliorates hyperglycemia and insulin resistance in HFD-fed mice. | Scientific Reports

Figure 2: Hepatic inhibition miR-291b-3p expression ameliorates hyperglycemia and insulin resistance in HFD-fed mice.

From: Hepatic MiR-291b-3p Mediated Glucose Metabolism by Directly Targeting p65 to Upregulate PTEN Expression

Figure 2

(A) Glucose tolerance test (GTT) in HFD-fed mice on 7 days after injection of adenovirus-miR-291b-3p-inbibitor (Ad-miR-291i) or adenovirus-GFP (Ad-NC). (B) Insulin tolerance test (ITT) in HFD-fed mice on 7 days after injection of Ad-miR-291i or Ad-NC. (C) Pyruvate tolerance test (PTT) in HFD-fed mice on 7 days after injection of Ad-miR-291i or Ad-NC. (D) Euglycemic-hyperinsulinemic clamp assay in HFD-fed mice on 7 days after injection of Ad-miR-291i or Ad-NC. (E) The glycogen content in the liver of HFD-fed mice on 7 days after injection of Ad-miR-291i or Ad-NC. (F) The glucose production in the liver of HFD-fed mice on 7 days after injection of Ad-miR-291i or Ad-NC. (G) The glycogen content in the NCTC1469 cells transfected with miR-291b-3p inhibitor (291i). (H) The glucose level in the medium of NCTC1469 cells transfected with 291i. Data are expressed as mean ± SEM (n = 5). *P < 0.05; **P < 0.01 vs. control group.

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