Figure 2: Performance of the proposed link prediction method on the GDSC Dataset.

(a) Each data point on the graph corresponds to a single cell line-drug pair. The x axis shows the predicted sensitivity score, the y axis shows the predicted resistance score for each cell line-drug pair. The color reflects the measured IC50 value for that pair: yellow indicates resistant and blue indicates sensitive. The black line (y = x) is the intuitive classification line of sensitive and resistant pairs as any data point below the line will have a higher sensitivity score than resistance (and vice versa). (b) Prediction performance as a function of the restart probability in random walk with restarts. (c) Prediction performance as a function of the parameter (ε) that controls the sparsity of the network profiles. The left-most point corresponds to using the full profiles (i.e. utilization of all genes in the network profiles). (b) and (c) show that when the network information used is very limited, performance decreases. For a, the following parameters were used: α = 0.7, ε = 1e − 5.