Figure 6: δ-TOS promotes hematopoietic stem and progenitor cell recovery after irradiation exposure. | Scientific Reports

Figure 6: δ-TOS promotes hematopoietic stem and progenitor cell recovery after irradiation exposure.

From: Succinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice

Figure 6: δ-TOS promotes hematopoietic stem and progenitor cell recovery after irradiation exposure.

Non-irradiated group (Non-IR) was administrated vehicle without irradiation. Irradiated group (IR) and δ-TOS group were respectively administrated with vehicle and δ-TOS (100 mg/kg) 24 h before & 1 h after 6.5 Gy TBI. (a) Representative flow cytometry of hematopoietic progenitor cells (HPCs, c-Kit+Lin−Sca1−) and hematopoietic stem cells (HSCs, c-Kit+Lin−Sca1+) in the BM of each group. Shown in P2, sca1 and c-Kit were gated on Lin− cells. (b) Quantifications and frequencies of HPCs in whole bone marrow cells on days 10 after irradiation. (c) Quantifications and frequencies of HSCs in whole bone marrow cells on days 10 after irradiation. Data represent the mean ± S.E.M. (n = 8); ***P < 0.001 vs. irradiated group.

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