Figure 7: δ-TOS promotes long term and short term hematopoietic stem cell recovery after irradiation exposure. | Scientific Reports

Figure 7: δ-TOS promotes long term and short term hematopoietic stem cell recovery after irradiation exposure.

From: Succinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice

Figure 7: δ-TOS promotes long term and short term hematopoietic stem cell recovery after irradiation exposure.

Non-irradiated group (Non-IR) was administrated vehicle without irradiation. Irradiated group (IR) and δ-TOS group were respectively administrated with vehicle and δ-TOS (100 mg/kg) 24 h before & 1 h after 6.5 Gy TBI. (a) Representative flow cytometry of LT-HSCs cells, ST-HSCs cells and MPP-HSCs in the BM of each group on days 10 after irradiation. Shown in P4, flt-3 and CD34 were gated on LSK cells. (b) Quantifications and frequencies of LT-HSCs cells in whole bone marrow cells on days 10 after irradiation. (c) Quantifications and frequencies of ST-HSCs cells in whole bone marrow cells on days 10 after irradiation. (d) Quantifications and frequencies of MPP-HSCs cells in whole bone marrow cells on days 10 after irradiation. Data represent the mean ± S.E.M. (n = 8); **P < 0.01; ***P < 0.001 vs. irradiated group.

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