Figure 1
From: Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B
(a) Inhibition curves for ciproxifan obtained with a spectrophotometric assay using human recombinant membrane-bound MAO A and MAO B. (b) Inhibition curves for ciproxifan in rat brain MAO A and MAO B measured radiometrically. Kynuramine (KYN, a) or serotonin (5-HT, b) were used as MAO A substrates. Kynuramine (KYN, a), benzylamine (BZA, a) or phenylethylamine (PEA, b) were used as MAO B substrates. Data represent mean ± s.e.m. of at least n = 3 independent experiments each performed at least in duplicates (global fit). The Ki values of ciproxifan for human histamine H3 receptors (hH3R, ∆) and rat histamine H3 receptors (rH3R, ▲) are indicated in the graphs1.
