Table 1 Published affinity data for ciproxifan.

From: Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B

Receptor

Ki [nM]

Receptor

Ki [nM]

rH3R

0.4–6.22,3,27,28,29

gpβ1b

125892

mH3R

0.5–0.830

gp M3c

31622

mkH3R

4127

gp5-HT3c

>3,1622

hH3R

46–1801,3,27

gp5-HT1Bd

>10,0002

hH1R

>10,0003

r5-HT1

1659831

hH2R

>10,0003

r5-HT2Ae

158482

hH4R

18623

r5-HT3

3023

hα2C

633

r5-HT4f

>1,9952

hα2A

433

  

rα1Da

3,9812

  
  1. gp = guinea pig, h = human, m = mouse, mk = monkey, r = rat.
  2. arat aorta.
  3. bguinea pig atrium.
  4. cguinea pig ileum.
  5. dguinea pig iliac.
  6. erat tail.
  7. frat esophagus.
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