Table 2 IC50 values and type of inhibition for ciproxifan, l-deprenyl, clorgyline, safinamide and moclobemide using kynuramine (KYN) or serotonin (5-HT) and benzylamine (BZA) or phenylethylamine (PEA) as MAO A and MAO B substrates, respectively.
From: Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B
|  | IC50 [μM] ± s.e.m (n) | IC50 [μM] ± s.e.m (n) | Inhibition Type | |||
|---|---|---|---|---|---|---|
hMAO | rMAO | |||||
A | B | A | B | |||
Substrate | KYN | BZA | KYN | 5-HT | PEA | Â |
Ciproxifan | 11.4 ± 1.2 (5) | 4.3 ± 0.7 (5) | 2.1 ± 0.3 (9) | 37.5 ± 0.2 (3) | 15.4 ± 0.3 (3) | Reversible |
Safinamide | n.d. | n.d. | 0.049 ± 0.001 (4) | n.d. | n.d. | Reversible20 |
Moclobemide | 568 ± 115 (3) | n.d. | n.d. | n.d. | n.d. | Reversible32 |
l -Deprenyl | 29.6 ± 3.9 (9) | n.d. | 0.037 ± 0.004 (5) | n.d. | n.d. | Mixed/Irreversible33 |
Clorgyline | 0.008 ± 0.001 (4) | n.d. | 1.3 ± 0.2 (4) | n.d. | n.d. | Mixed/Irreversible33 |
