Figure 2: Effect of mussel sample 1786/2012 over INa current activity. | Scientific Reports

Figure 2: Effect of mussel sample 1786/2012 over INa current activity.

From: The association of bacterial C9-based TTX-like compounds with Prorocentrum minimum opens new uncertainties about shellfish seafood safety

Figure 2

Automated patch clamp experiments were carried out in hNav1.6 transfected cells. INa magnitude is expressed as percentage of basal current. (A) Dose-response inhibition of serial dilutions of 1786/2012 mussel sample over INa. 0.4, 2 and 4 μl of extract were added to 200 μl of extracellular solution. Significant differences (*)p < 0.05. (B) Dose-response inhibition of TTX standard over INa with an IC50 of 0.43 to 1.2 nM. A discontinuous line marks the 50% of sodium current (A and B) and the corresponding TTX standard concentration (B).

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