Figure 3: Effect of P. minimum extracts growing in different conditions over INa activity. | Scientific Reports

Figure 3: Effect of P. minimum extracts growing in different conditions over INa activity.

From: The association of bacterial C9-based TTX-like compounds with Prorocentrum minimum opens new uncertainties about shellfish seafood safety

Figure 3

Automated patch clamp experiments were carried out in hNav1.6 transfected cells. INa magnitude is expressed as percentage of basal current. (A) Effect of extracts from ccmp1529 strain cultured at 19 and 24 °C and different light exposures over INa. (B) Effect of extracts from ccmp2956 strain cultured at 19 and 24 °C, two light exposures and two different salinities over INa. (C) Effect of extracts from ccmp2811 strain cultured at 19 °C over INa. (D) TTX dose-response inhibition of INa. (E and F) Representative current traces of INa in the presence of an extract from ccmp1529 and TTX. Results are mean ± SEM of 3 experiments, each performed in duplicate. Significant differences *p < 0.05, **p < 0.01.

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