Figure 4: Modulation of ryanodine receptors affected SCO pattern in primary cultured rat cardiomyocytes. | Scientific Reports

Figure 4: Modulation of ryanodine receptors affected SCO pattern in primary cultured rat cardiomyocytes.

From: Modification of distinct ion channels differentially modulates Ca2+ dynamics in primary cultured rat ventricular cardiomyocytes

Figure 4

(A) Representative traces of ryanodine-induced alterations in Ca2+ dynamics in cardiomyocytes as a function of time. (B) Representative traces of FLA-365-induced alterations in Ca2+ dynamics in cardiomyocytes as a function of time. (C) Concentration-response relationship curves of ryanodine reduced SCO frequency and amplitude and prolonged FWHM. (D) Concentration-response relationship of FLA-365-induced SCO frequency decrease. The experiments were repeated in three independent cultures each with three replicates.

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