Figure 6: 4-AP and E-4031 affected SCOs in rat cardiomyocyte cultures. | Scientific Reports

Figure 6: 4-AP and E-4031 affected SCOs in rat cardiomyocyte cultures.

From: Modification of distinct ion channels differentially modulates Ca2+ dynamics in primary cultured rat ventricular cardiomyocytes

Figure 6

(A) Representative traces of 4-AP-induced alterations in Ca2+ dynamics as a function of time. 4-AP produced irregularity on SCO pattern with occurrence of SCO bursts. (B) 4-AP was without effect on SCO frequency. (C) Concentration-response relationship curve for 4-AP altered SCO amplitude. (D) Concentration-response relationship curve for 4-AP altered SCO/burst duration (FWHM). (E) Representative traces of E-4031-induced alterations in Ca2+ dynamics as a function of time. (F) Concentration-response relationship curve of 4-AP suppressing SCO frequency. (G) E-4031 did not affect SCO amplitude. H, Concentration-response relationship curve for 4-AP increased SCO/burst duration (FWHM). The experiments were repeated in three independent cultures each with three replicates.

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