Table 3 Genetics and demographic risk factors for neovascular Age-related macular degeneration.

From: Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans

 

Neovascular AMD (n = 150) vs Controls (n = 1,267)

Typical AMD (n = 64) vs Controls (n = 1,267)

PCV (n = 86) vs Controls (n = 1,267)

Age and gender adjusted OR (95% CI)

p

Multiple Adjusted# OR (95% CI)

p

Age and gender adjusted OR (95%)

p

Multiple Adjusted* OR (95%)

p

Age and gender adjusted OR (95%)

p

Multiple Adjusted # OR (95%)

p

Age, years

1.07 (1.05, 1.09)

<0.001

1.07 (1.03, 1.11)

<0.001

1.09 (1.06, 1.13)

<0.001

1.09 (1.01, 1.17)

0.021

1.05 (1.03, 1.08)

<0.001

1.07 (1.03, 1.12)

0.001

Gender, female

0.89 (0.62, 1.27)

0.517

0.80 (0.39, 1.66)

0.552

0.68 (0.39, 1.18)

0.170

0.41 (0.12, 1.40)

0.154

1.05 (0.67, 1.66)

0.827

0.92 (0.39, 2.18)

0.851

Body Mass Index (BMI)

1.06 (1.01, 1.12)

0.014

1.04 (0.96, 1.12)

0.364

1.11 (1.03, 1.19)

0.006

1.13 (0.99, 1.30)

0.081

1.04 (0.97, 1.10)

0.279

1.00 (0.90, 1.10)

0.939

Hypertension

0.92 (0.61, 1.38)

0.675

—

 

0.72 (0.40, 1.30)

0.272

0.36 (0.12, 1.08)

0.068

1.11 (0.66, 1.89)

0.691

—

—

Creatinine

1.00 (1.00, 1.01)

0.554

—

 

1.00 (1.00, 1.01)

0.150

1.01 (0.99, 1.02)

0.527

1.00 (0.99, 1.01)

0.576

—

—

Smoking status

 Nonsmoker

Reference

 

Reference

 

Reference

   

Reference

 

Reference

 

 Current smoker

1.64 (0.94, 2.86)

0.084

1.73 (0.75, 4.00)

0.199

1.17 (0.48, 2.85)

0.734

—

—

2.06 (1.03, 4.10)

0.040

2.12 (0.82, 5.47)

0.120

 Past smoker

1.63 (1.00, 2.65)

0.052

2.22 (1.05, 4.68)

0.037

1.42 (0.71, 2.85)

0.327

—

—

1.77 (0.93, 3.37)

0.081

2.89 (1.23, 6.79)

0.015

Current and past smoker

      

—

—

    

 No

Reference

 

Reference

 

Reference

   

Reference

 

Reference

 

 Yes

1.37 (0.81, 2.30)

0.242

1.30 (0.60, 2.81)

0.510

1.02 (0.44, 2.38)

0.962

  

1.67 (0.88, 3.16)

0.114

1.44 (0.61, 3.41)

0.410

Cardiovascular disease

0.81 (0.42, 1.55)

0.523

—

 

1.23 (0.54, 2.76)

0.623

—

—

0.48 (0.17, 1.37)

0.170

0.16 (0.02, 1.31)

0.088

Stroke

0.57 (0.17, 1.92)

0.362

—

 

0.80 (0.18, 3.55)

0.772

—

—

0.35 (0.05, 2.64)

0.309

—

 

Diabetes

0.82 (0.57, 1.17)

0.277

1.00 (0.46, 2.16)

1.000

1.08 (0.64, 1.83)

0.762

—

—

0.66 (0.41, 1.06)

0.088

0.64 (0.25, 1.61)

0.344

 Glucose

0.92 (0.83, 1.03)

0.159

0.96 (0.81, 1.13)

0.589

0.95 (0.80, 1.13)

0.544

—

—

0.91 (0.79, 1.05)

0.195

0.96 (0.79, 1.16)

0.665

 HbA1c

0.84 (0.67, 1.06)

0.147

0.82 (0.45, 1.49)

0.520

0.89 (0.65, 1.23)

0.490

—

—

0.81 (0.60, 1.11)

0.187

1.00 (0.51, 1.95)

1.000

Total Cholesterol

1.00 (0.85, 1.18)

0.963

—

 

1.00 (0.79, 1.29)

0.956

—

—

1.01 (0.82, 1.25)

0.916

—

—

LDL-cholesterol

1.08 (0.84, 1.39)

0.565

—

 

1.26 (0.85, 1.86)

0.246

1.66 (1.01, 2.73)

0.046

1.00 (0.73, 1.37)

0.987

—

—

HDL-cholesterol

1.89 (1.11, 3.24)

0.020

1.79 (0.97, 3.31)

0.062

2.43 (1.06, 5.57)

0.035

3.61 (1.46, 8.94)

0.006

1.63 (0.81, 3.27)

0.170

1.09 (0.46, 2.59)

0.839

Axial Length

0.85 (0.76, 0.96)

0.009

0.80 (0.65, 0.99)

0.039

0.85 (0.75, 0.98)

0.019

0.76 (0.53, 1.09)

0.135

0.82 (0.68, 0.99)

0.039

0.81 (0.64, 1.04)

0.101

Pseudophakia

1.37 (0.88, 2.12)

0.165

1.16 (0.55, 2.43)

0.694

1.51 (0.81, 2.82)

0.193

2.68 (0.75, 9.54)

0.127

1.24 (0.70, 2.21)

0.456

—

 

CFH (rs800292_A)

0.63 (0.48, 0.82)

0.001

0.55 (0.36, 0.86)

0.009

0.69 (0.46, 1.01)

0.059

0.49 (0.21, 1.10)

0.085

0.59 (0.42, 0.83)

0.003

0.62 (0.37, 1.02)

0.062

ARMS2 (rs10490924_T)

2.20 (1.69, 2.85)

<0.001

2.70 (1.77, 4.11)

<0.001

2.64 (1.77, 3.94)

<0.001

3.57 (1.63, 7.83)

0.001

1.99 (1.44, 2.76)

<0.001

2.53 (1.56, 4.11)

<0.001

CETP (rs3764261_A)

1.04 (0.75, 1.45)

0.793

—

—

1.00 (0.61, 1.64)

0.994

—

—

1.07 (0.71, 1.62)

0.741

—

—

D442G (rs2303790_G)

1.23 (0.61, 2.49)

0.559

—

—

1.39 (0.53, 3.65)

0.503

—

—

1.12 (0.44, 2.89)

0.807

—

—

  1. #Adjusted for age, gender, BMI, diabetes, smoking, glucose, Hba1c, HDL cholesterol, axial length, cataract surgery, CFH and ARMS2.
  2. *Adjusted for age, gender, BMI, hypertension, creatinine, LDL cholesterol, HDL cholesterol, axial length, cataract surgery, CFH and ARMS2.
  3. SD standard deviation; BMI body mass index; LDL-cholesterol Low density Lipoprotein- cholesterol; HDL-cholesterol High density Lipoprotein cholesterol. **Adjusted for age, gender, BMI, diabetes, cardiovascular disease, smoking, glucose, HbA1c, HDL cholesterol, axial length, CFH and ARMS2.
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