Figure 6: NLS inhibited tumor growth in human PC3 xenograft nude mouse model. | Scientific Reports

Figure 6: NLS inhibited tumor growth in human PC3 xenograft nude mouse model.

From: Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling

Figure 6

Nude mice (n = 10) implanted with PC3-luc cells (2 × 106/mouse) by subcutaneous injection were treated for 24 consecutive days orally with NLS (52 and 26 mg/kg/day). Paclitaxel (PTX, 20 mg/kg), used as reference drug for positive control, was administered intraperitoneally once per week. Treatment was started 6 days after cell injection with the average tumor volume of about 50 mm3 for the treatment and control groups. (A) Tumor growth curves in treatment and control groups. Data are expressed as mean ± SD. Compared to control group: **p < 0.01. (B) Body weight measurements of mice in different groups throughout the treatment course. There is no significant loss of body weight in NLS treatment groups compared to that of control group. (C) Bioluminescence imaging of PC3 xenograft tumors in different groups at the end of experiments.

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