Figure 4: Comparison of performance of MCI technology versus standard multiwell plates.
From: Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters
Dose response curves with doxorubicin and MCF-7 cells were generated using both approaches, after 24 hrs of incubation. Cell viability analysis at each drug concentration was based on ~600 cells, in both the approaches. Each data point represents the mean response and the error bar corresponds to standard deviation from 3 replicates. The solid line is the average dose response curve, which was generated by fitting the standard Hill equation. The half maximal inhibitory concentrations (IC50) for 96-wellplate and microfluidic device are not statistically significant (p > 0.05).
