Figure 8: Potential mechanism of action of OSGIN1-mediated cellular protection. | Scientific Reports

Figure 8: Potential mechanism of action of OSGIN1-mediated cellular protection.

From: The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

Figure 8

(a) Interaction of MMF with cysteine residues on KEAP1 results in an allosteric conformational change in the KEAP1 protein so that NRF2 is no longer targeted for ubiquitination and proteasomal degradation. This allows NRF2 to accumulate in the cytoplasm and translocate to the nucleus where it can regulate the transcription of various genes including, OSGIN1. OSGIN1 transcript expression is then translated to a 61 kDa protein that can induce the accumulation of P53 by an unknown mechanism. (b) P53 protein induced by OSGIN1-61 kDa can then translocate to the nucleus and induce gene transcription.

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