Table 2 Univariate and multivariate analysis for patient survival.

From: Impact of Including Peritumoral Edema in Radiotherapy Target Volume on Patterns of Failure in Glioblastoma following Temozolomide-based Chemoradiotherapy

Variables

OS

PFS

2-year (%)

Univariate

Multivariate

2-year (%)

Univariate

Multivariate

p value

p value

p value

p value

Age

 

0.004

0.032

 

0.719

0.862

 <60-year

50

  

35

  

 ≥60-year

34

  

36

  

Surgery

 

<0.001

0.004

 

<0.001

0.002

 GTR

57

  

45

  

 <GTR

31

  

27

  

RT dose

 

0.766

  

0.479

 

 <70 Gy

43

  

36

  

 ≥70 Gy

48

  

29

  

KPS

 

0.009

0.364

 

0.217

0.701

 <80

33

  

33

  

 ≥80

51

  

38

  

Multiplicity

 

0.004

0.075

 

0.040

0.113

 Yes

27

  

22

  

 No

47

  

38

  

Ventricle involvement

 

0.021

0.363

 

0.103

0.507

 Yes

33

  

23

  

 No

47

  

39

  

MGMT methylation

 

0.002

0.010

 

0.005

0.012

 Methylation

61

  

53

  

 Unmethylation

34

  

22

  

 Unknown

32

  

45

  

Edema inclusion

 

0.535

  

0.657

 

 Yes

42

  

37

  

 No

49

  

29

  

Pseudoprogression/RN

 

0.090

  

0.755

 

 Yes

58

  

38

  

 No

34

  

33

  
  1. Abbreviations: GTR = gross total resection; RT = radiotherapy; KPS = Karnofsky performance status scale; MGMT = O6-methylguanine-DNA methyltransferase; RN = radiation necrosis; OS = overall survival; PFS = progression-free survival; HR = hazard ratio; CI = confidence interval.
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