Figure 4: Cross-sectional capillary density map in the retina of a normal human participant, and proposed segmentation boundaries.

The top 14.2 mm (x) by 0.7 mm (z) image was obtained by montaging four 4.5 × 4.5 mm PR-OCTA volumes and selecting a cross-sectional slab along the maculopapillary axis (Fig. 2). The capillary density is measured within super-voxels of 0.1 × 0.8 × 0.01 mm (x × y × z). Three layers of concentrated capillary density could be seen in the retina (top layers of upper image): superior vascular complex, intermediate capillary plexus, and deep capillary plexus. One layer of high capillary density is seen in the choriocapillaris (bottom layer). Proposed segmentation boundaries are showen in lower image (white lines) with corresponding structural OCT layers. (OCT = optical coherence tomography, RPCP = radial peripapillary capillary plexus, SVP = superficial vascular plexus, ICP = intermediate capillary plexus, DCP = deep capillary plexus, GCC = ganglion cell complex, OPL = outer plexiform layer, RPE = retinal pigment epithelium).