Figure 1: Staufen1 is overexpressed in human rhabdomyosarcoma. | Scientific Reports

Figure 1: Staufen1 is overexpressed in human rhabdomyosarcoma.

From: Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events

Figure 1: Staufen1 is overexpressed in human rhabdomyosarcoma.

Tissue microarrays were used to evaluate Staufen1 expression by immunohistochemistry in human normal skeletal muscle and primary rhabdomyosarcoma core biopsies. (a) Intensity scoring of tissues was performed and analyzed using a 4-point scoring system with 0–1 = low expression, 2–3 = moderate expression and 4 = high expression. Representative images of scored Staufen1 staining in normal skeletal muscle tissue (n = 8), Embryonal Rhabdomyosarcoma (ERMS) (n = 26), and Alveolar Rhabdomyosarcoma (ARMS) (n = 24) using anti-Staufen1 antibodies (brown) and hematoxylin stain for nuclei (blue); 20X objective, scale bar = 50 μm. Insert represents lower magnification images at 5X magnification to visualize total core biopsy sample. (b) Quantification of the mean intensity score, data are Mean ± SEM, *P < 0.05.

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