Figure 5: Effects of E2 treatment on synaptic markers (PDS95, Synaptophysin) and ultrastructure of synapses of hippocampal CA1 neurons at 3 m after BCCAO. | Scientific Reports

Figure 5: Effects of E2 treatment on synaptic markers (PDS95, Synaptophysin) and ultrastructure of synapses of hippocampal CA1 neurons at 3 m after BCCAO.

From: Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia

Figure 5: Effects of E2 treatment on synaptic markers (PDS95, Synaptophysin) and ultrastructure of synapses of hippocampal CA1 neurons at 3 m after BCCAO.

(a) Immunofluorescent staining for DAPI (Blue), PSD95 (Green) and Synaptophysin (Red) in hippocampal CA1 region for various groups (Sham, Sh; Placebo, Pla; Estradiol, E2) n = 5, Scale bars = 50 μm and magnification 63×. (b,c) Western blot analysis for PSD95 and Synaptophysin. *P < 0.05 vs. sham 3 m group; #P < 0.05 vs. Pla 3 m group. n = 5–6; (d) Ultrastructure of synapses of hippocampal CA1 neurons (S: Presynaptic; Red star: Postsynaptic).

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