Figure 8: Summary diagram of the proposed mechanisms underlying progressive lesions in vascular dementia and the benificial effects of E2 administration during the first 3 months of BCCAO. | Scientific Reports

Figure 8: Summary diagram of the proposed mechanisms underlying progressive lesions in vascular dementia and the benificial effects of E2 administration during the first 3 months of BCCAO.

From: Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia

Figure 8: Summary diagram of the proposed mechanisms underlying progressive lesions in vascular dementia and the benificial effects of E2 administration during the first 3 months of BCCAO.

The rats underwent BCCAO 3 m exhibit memory decline, which is caused by axonal damage, reduction in hippocampal spine density and synaptic proteins. E2 administration for 3 m reduces these key pathogenic events, and further to underlie the later beneficial effects on preventing apoptosis and dementia-related protein expression, as well as preservation of cognitive function observed at 6 months after BCCAO in E2-treated animals.

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