Figure 1: Overall analysis pipeline. | Scientific Reports

Figure 1: Overall analysis pipeline.

From: An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system

Figure 1

(a) DRG and neurofibroma tumors were dissociated and sorted into SC and macrophage populations. (b) DEGs were detected in comparisons of 7- to 1-month-old cell populations. These DEG lists were used to run gene set enrichment analysis and to reconstruct a ligand-receptor interaction map. Combined with NetWalk analysis, we narrowed down our target gene lists by identifying the most relevant gene network modules in neurofibroma. Cytokine arrays were used to validate the differential protein level changes of several target genes (between wild-type DRG and neurofibroma tumors).

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