Figure 2: Average changes in HbA1c, fasting glucose, HOMA-IR, HOMA-β, ratio of HOMA-β to HOMA-IR, and fasting insulin from 9 years before diagnosis/last exam by BMI trajectory.

Solid lines in red indicate estimated trajectories for the groups that developed diabetes, while dashed lines in blue indicate trajectories for each group that did not develop diabetes. Square, high BMI; triangle, medium BMI; circle, low BMI.