Figure 4: An eQTL polymorphism of MYBL2 is associated with poor prognosis of breast cancer patients.
From: B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers
(A,B) The distribution of (A) MYBL2 and (B) A3B expression sorted by genotype of rs619289 in whole-blood samples was queried from the GTEx Portal. The number of samples harboring TT, CT, and CC alleles was 21, 92, and 225, respectively. (C) Disease-free survival (DFS) of breast cancer patients (stage ≥II) harboring wild-type (CC, 487 samples) or variant-type (CT + TT, 230 samples) rs619289. The data were adjusted for factors associated with breast cancer progression, e.g., patient age, tumor stage, and hormone therapy status.
