Figure 5: Upregulation of MYBL2 is evident in multiple cancer types, and its expression correlates with the median level of somatic mutation load.
From: B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers
(A) Each data point represents relative MYBL2 expression of one normal or tumor sample, as queried from TCGA RNA sequence database. The x axis denotes a total of 21 cancer types, and blue and pink horizontal bars indicate the median MYBL2 expression (relative to that of TBP) for each normal and tumor cancer type, respectively. Asterisks indicate statistically significant MYBL2 upregulation in the tumor type relative to the corresponding normal tissue. (B,C) Correlation between C-to-T mutation load (y axis) against (B) A3B or (C) MYBL2 mRNA level relative to TBP mRNA (x axis). Each data point represents both median values for one cancer type, and the line is the best fit for visualization. The correlation between them was calculated using Spearman’s correlation test. See also Supplementary Tables S4 and S6. (D) Each data point and 95% confidence interval represents the correlation status (Spearman’s r, y axis) between A3B and MYBL2 mRNA levels for one TCGA cancer type. A total of 16 TCGA cancer types were included in the x axis and ranked according to somatic mutation load. See also Supplementary Table S2.
